Genetics in psychiatry: common variant association studies.


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Authors
Buxbaum, Joseph D 
Devlin, Bernie 
Abstract

Many psychiatric conditions and traits are associated with significant heritability. Genetic risk for psychiatric conditions encompass rare variants, identified due to major effect, as well as common variants, the latter analyzed by association analyses. We review guidelines for common variant association analyses, undertaking after assessing evidence of heritability. We highlight the importance of: suitably large sample sizes; an experimental design that controls for ancestry; careful data cleaning; correction for multiple testing; small P values for positive findings; assessment of effect size for positive findings; and, inclusion of an independent replication sample. We also note the importance of a critical discussion of any prior findings, biological follow-up where possible, and a means of accessing the raw data.

Description
Keywords
0604 Genetics, Population & Society, Mental Health, Genetics, Human Genome, Clinical Research, Mental Health, 2.1 Biological and endogenous factors
Journal Title
Mol Autism
Conference Name
Journal ISSN
2040-2392
2040-2392
Volume Title
Publisher
Springer Science and Business Media LLC
Sponsorship
Medical Research Council (G0600977)