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In vivo recordings of brain activity using organic transistors.

Published version
Peer-reviewed

Type

Article

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Authors

Khodagholy, Dion 
Doublet, Thomas 
Quilichini, Pascale 
Gurfinkel, Moshe 
Leleux, Pierre 

Abstract

In vivo electrophysiological recordings of neuronal circuits are necessary for diagnostic purposes and for brain-machine interfaces. Organic electronic devices constitute a promising candidate because of their mechanical flexibility and biocompatibility. Here we demonstrate the engineering of an organic electrochemical transistor embedded in an ultrathin organic film designed to record electrophysiological signals on the surface of the brain. The device, tested in vivo on epileptiform discharges, displayed superior signal-to-noise ratio due to local amplification compared with surface electrodes. The organic transistor was able to record on the surface low-amplitude brain activities, which were poorly resolved with surface electrodes. This study introduces a new class of biocompatible, highly flexible devices for recording brain activity with superior signal-to-noise ratio that hold great promise for medical applications.

Description

Keywords

Animals, Brain, Brain Mapping, Electroencephalography, Electrophysiological Phenomena, Epilepsy, Rats, Rats, Long-Evans, Rats, Wistar, Reproducibility of Results, Somatosensory Cortex, Transistors, Electronic

Journal Title

Nat Commun

Conference Name

Journal ISSN

2041-1723
2041-1723

Volume Title

4

Publisher

Springer Science and Business Media LLC