The efficiency of single-junction perovskite solar cells (PSCs) has reached 26.1% and greater attention is turning to improving their intrinsic and environmental stability. The optoelectronic properties of perovskites and interaction within a device depend not only on their component atoms but also neighboring atoms. It is necessary to further understand and explore the interaction between the functional material and device. Here, we summarize the hydrogen bonding in PSCs, including each functional layer and interface. Despite being a weak force, hydrogen bonding can greatly influence material properties. Effects on crystallization, stability, ion migration, phase transition etc., and strategies to precisely adjust hydrogen bonding for target properties are discussed. We observe that the research on hydrogen bonding in PSC is still controversial and poorly understood, thus it is often overlooked. With greater understanding, we anticipate researchers can further harness hydrogen bonding as a versatile tool to solve technical challenges in PSCs.