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Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Ingham, Richard J 
Battilocchio, Claudio  ORCID logo  https://orcid.org/0000-0002-4601-8527
Hawkins, Joel M 
Ley, Steven V 

Abstract

Here we describe the use of a new open-source software package and a Raspberry Pi(®) computer for the simultaneous control of multiple flow chemistry devices and its application to a machine-assisted, multi-step flow preparation of pyrazine-2-carboxamide - a component of Rifater(®), used in the treatment of tuberculosis - and its reduced derivative piperazine-2-carboxamide.

Description

Keywords

automation, flow chemistry, hydration, hydrogenation, sustainable processing

Journal Title

Beilstein J Org Chem

Conference Name

Journal ISSN

1860-5397
1860-5397

Volume Title

10

Publisher

Beilstein Institut