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Toward a global and reproducible science for brain imaging in neurotrauma: the ENIGMA adult moderate/severe traumatic brain injury working group.

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Babikian, Talin 
Bigler, Erin D 
Caeyenberghs, Karen 
Conde, Virginia 


The global burden of mortality and morbidity caused by traumatic brain injury (TBI) is significant, and the heterogeneity of TBI patients and the relatively small sample sizes of most current neuroimaging studies is a major challenge for scientific advances and clinical translation. The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Adult moderate/severe TBI (AMS-TBI) working group aims to be a driving force for new discoveries in AMS-TBI by providing researchers world-wide with an effective framework and platform for large-scale cross-border collaboration and data sharing. Based on the principles of transparency, rigor, reproducibility and collaboration, we will facilitate the development and dissemination of multiscale and big data analysis pipelines for harmonized analyses in AMS-TBI using structural and functional neuroimaging in combination with non-imaging biomarkers, genetics, as well as clinical and behavioral measures. Ultimately, we will offer investigators an unprecedented opportunity to test important hypotheses about recovery and morbidity in AMS-TBI by taking advantage of our robust methods for large-scale neuroimaging data analysis. In this consensus statement we outline the working group's short-term, intermediate, and long-term goals.



Brain injury, ENIGMA, Neurodegeneration, Open Science, Radiology, Rehabilitation, Adult, Brain, Brain Injuries, Traumatic, Humans, Magnetic Resonance Imaging, Neuroimaging, Reproducibility of Results

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Brain Imaging Behav

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Springer Science and Business Media LLC


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Academy of Medical Sciences (unknown)
National Health and Medical Research Council Career Development Fellowship and an ACURF Program grant by the Australian Catholic University (ACU) to Dr. Caeyenberghs. NIH/NINDS/NICHD 1U01NS086625-01 to Dr. Dams-O'Connor. K99NS096116 to Dr. Dennis. PA Health Research Grant SAP #4100077082 to Dr. Hillary. High Impact Doctoral Research Assistantship from Brigham Young University to Cooper Hodges. NIH grant R01 NS 100973 and DoD contract W81XWH-18-1-0413 to Dr. Irimia. NIH/NINDS award K23NS101036 to Dr. Jha. TBI Endpoints Development (TED) to Dr. Levin. DOD USAMRMC (PT13078) to Dr. Li. Israel Innovation Authority, “Magneton” Grant to Dr Livny. NIH/NIMH/NINDS through grant numbers DP5-OD-021352, R01-DC016800, R01- DC014960 to Dr. Medaglia. DKM is an Emeritus Senior Investigator of the National Institute for Health Research, UK, and is supported by the CENTER-TBI grant from the European Union. Tiny Blue Dot Foundation to Dr. Monti. Academy of Medical Science / The Health Foundation Clinician Scientist Fellowship to Dr. Newcombe. Transport Accident Commission to Dr. Ponsford. UK Dementia Research Institute to Dr. Sharp. NHMRC Early Career Fellowship to Dr. Spitz. U54 EB020403, R01 MH116147, R56 AG058854, P41 EB015922, R01 MH111671 to Dr. Thompson. The European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (ERC Starting Grant, Grant agreement No. 802998) and the Research Council of Norway (249795) to Dr. Westlye.