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Harnessing non-covalent interactions to exert control over regioselectivity and site-selectivity in catalytic reactions.

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Davis, Holly J 


Asymmetric catalysis has been revolutionised by the realisation that attractive non-covalent interactions such as hydrogen bonds and ion pairs can act as powerful controllers of enantioselectivity when incorporated into appropriate small molecule chiral scaffolds. Given these tremendous advances it is surprising that there are still a relatively limited number of examples of non-covalent interactions being harnessed for control of regioselectivity or site-selectivity in catalysis, two other fundamental selectivity aspects facing the synthetic chemist. This perspective examines the progress that has been made in this area thus far using non-covalent interactions in conjunction with transition metal catalysis as well as in the context of purely organic catalysts. We hope this will highlight the great potential in this approach for designing selective catalytic reactions.



0306 Physical Chemistry (incl. Structural), 0302 Inorganic Chemistry, 0305 Organic Chemistry

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Chem Sci

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Royal Society of Chemistry (RSC)
Engineering and Physical Sciences Research Council (EP/N005422/1)
We are grateful to the Royal Society for a University Research Fellowship (to RJP) and to Professors Matthew J. Gaunt and Steven V. Ley for support and useful discussions. We are grateful to the EPSRC and Pfizer for a CASE studentship (to HJD) and to David Blakemore (Pfizer) and Alan D. Brown for useful discussion.