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The unfolded protein response in immunity and inflammation.

Accepted version
Peer-reviewed

Type

Article

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Authors

Grootjans, Joep 
Kaser, Arthur 
Kaufman, Randal J 
Blumberg, Richard S 

Abstract

The unfolded protein response (UPR) is a highly conserved pathway that allows the cell to manage endoplasmic reticulum (ER) stress that is imposed by the secretory demands associated with environmental forces. In this role, the UPR has increasingly been shown to have crucial functions in immunity and inflammation. In this Review, we discuss the importance of the UPR in the development, differentiation, function and survival of immune cells in meeting the needs of an immune response. In addition, we review current insights into how the UPR is involved in complex chronic inflammatory diseases and, through its role in immune regulation, antitumour responses.

Description

Keywords

Animals, Endoplasmic Reticulum, Endoplasmic Reticulum Stress, Host-Pathogen Interactions, Humans, Immune System, Immunity, Inflammation, Signal Transduction, Unfolded Protein Response

Journal Title

Nat Rev Immunol

Conference Name

Journal ISSN

1474-1733
1474-1741

Volume Title

16

Publisher

Springer Science and Business Media LLC
Sponsorship
Wellcome Trust (106260/Z/14/Z)
European Research Council (648889)
European Research Council (260961)
This work was supported by the Netherlands Organization for Scientific Research Rubicon grant 825.13.012 (J.G.); US National Institutes of Health (NIH) grants DK044319, DK051362, DK053056 and DK088199, and the Harvard Digestive Diseases Center (HDDC) grant DK034854 (R.S.B.); National Institutes of Health grants DK042394, DK088227, DK103183 and CA128814 (R.J.K.); and European Research Council (ERC) Starting Grant 260961, ERC Consolidator Grant 648889, and the Wellcome Trust Investigator award 106260/Z/14/Z (A.K.).