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What is Multiparametric-MRI of the Prostate and Why Do We Need It?

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Post-Prostate cancer is the second leading cause of cancer death in men. Prostate-specific antigen (PSA) testing has led to an over-diagnosis of relatively indolent disease, which has been further compounded by the limitations of traditional diagnosis by transrectal ultrasound-guided biopsy. Improvements in MRI technique and, in particular, functional imaging have enabled the radiologist to play a key role in the risk stratification and management of patients, with a drive to utilizing MRI early in the diagnostic pathway. However, the technique remains challenging both in the acquisition of images and in their interpretation, highlighting the need for the recent push towards greater standardisation. The benefits and limitations of MRI are discussed, along with future directions in the field.


This is the final version of the article. It first appeared from iMedPub via


prostate cancer, multiparametric MRI, pre-biopsy MRI

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Journal of Imaging and Interventional Radiology

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The author acknowledges research support from National Institute of Health Research Cambridge Biomedical Research Centre, Cancer Research UK, Cancer Research UK and the Engineering and Physical Sciences Research Council Imaging Centre in Cambridge and Manchester and the Cambridge Experimental Cancer Medicine Centre.