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The role of hydrogen peroxide in hip arthroplasty: A narrative review.

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cam.issuedOnline2021-07-11
dc.contributor.authorZhou, Andrew Kailin
dc.contributor.authorGirish, Milind
dc.contributor.authorThahir, Azeem
dc.contributor.authorAn Lim, Jiang
dc.contributor.authorTran, Caitlyn
dc.contributor.authorPatel, Shaan
dc.contributor.authorKrkovic, Matija
dc.contributor.orcidZhou, Andrew Kailin [0000-0001-6656-8123]
dc.contributor.orcidGirish, Milind [0000-0003-0599-5265]
dc.contributor.orcidAn Lim, Jiang [0000-0003-1610-7956]
dc.contributor.orcidTran, Caitlyn [0000-0002-1798-8938]
dc.contributor.orcidPatel, Shaan [0000-0003-2657-8874]
dc.date.accessioned2022-06-29T19:50:55Z
dc.date.available2022-06-29T19:50:55Z
dc.date.issued2022
dc.date.updated2022-06-29T19:50:54Z
dc.description.abstractHydrogen peroxide has become more commonly used in hip arthroplasties due to high risk of periprosthetic infections. Its purported roles include irrigation, haemostasis, reduction of aseptic loosening and attachment of antibiotics. However, current literature does not provide conclusive evidence on the efficacy of hydrogen peroxide in preventing aseptic loosening, with some controversy around whether it in fact contributes to aseptic loosening. The complications of hydrogen peroxide across medicine are well distinguished; however, the risks within orthopaedic surgery and hip arthroplasties are not well known. Beyond cytotoxicity, the most dangerous reported risk associated with hydrogen peroxide in hip arthroplasties was an oxygen embolism in an unvented femoral canal and acrylic bone cement, consequentially leading to cardiac arrest. However, it may be inappropriate to solely attribute the oxygen embolism to the use of hydrogen peroxide and thus if used appropriately, hydrogen peroxide may have a justifiable role in hip arthroplasty surgery. In this narrative review, we present the current uses of hydrogen peroxide while evaluating its associated risks. We have summarised the key indications and aggregated recommendations to provide guidelines for the use of hydrogen peroxide in hip arthroplasty.
dc.identifier.doi10.17863/CAM.86030
dc.identifier.eissn2515-7949
dc.identifier.issn1750-4589
dc.identifier.other10.1177_1750458921996259
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338617
dc.languageen
dc.language.isoeng
dc.publisherSAGE Publications
dc.publisher.urlhttp://dx.doi.org/10.1177/1750458921996259
dc.subjectArthroplasty
dc.subjectEmbolism
dc.subjectHydrogen peroxide
dc.subjectIrrigation
dc.subjectProsthesis loosening
dc.subjectArthroplasty, Replacement, Hip
dc.subjectHip Prosthesis
dc.subjectHumans
dc.subjectHydrogen Peroxide
dc.subjectOrthopedics
dc.subjectOxygen
dc.subjectProsthesis Failure
dc.titleThe role of hydrogen peroxide in hip arthroplasty: A narrative review.
dc.typeArticle
prism.endingPage182
prism.issueIdentifier7-8
prism.publicationNameJ Perioper Pract
prism.startingPage178
prism.volume32
rioxxterms.freetoread.startdate2021-07-11
rioxxterms.licenseref.startdate2021-07-11
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1177/1750458921996259

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