Repository logo
 

Favipiravir and zanamivir cleared infection with influenza B in a severely immunocompromised child

Accepted version
Peer-reviewed

No Thumbnail Available

Type

Article

Change log

Authors

Lumby, Casper 
Zhao, Lei 
Oporto, Macarena 
Best, Tim 
Tutill, Helena 

Abstract

A combination of favipiravir and zanamivir successfully cleared influenza B infection in a child who had undergone bone marrow transplant for X-linked severe combined immunodeficiency, with no recovery of T lymphocytes. Deep sequencing of viral samples illuminated the within-host dynamics of infection, demonstrating the effectiveness of favipiravir in this case.

Description

Keywords

favipiravir, genome sequencing, influenza, zanamivir, Amides, Antiviral Agents, Child, Humans, Influenza, Human, Pyrazines, Zanamivir

Journal Title

Clinical Infectious Diseases

Conference Name

Journal ISSN

1058-4838
1537-6591

Volume Title

Publisher

Oxford University Press

Rights

All rights reserved
Sponsorship
Wellcome Trust (101239/Z/13/Z)
Wellcome Trust (101239/Z/13/A)
Isaac Newton Trust (Minute 18.23(i))
Isaac Newton Trust