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Regulation of regulatory T cells in cancer.

Accepted version
Peer-reviewed

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Abstract

The inflammatory response to transformed cells forms the cornerstone of natural or therapeutically induced protective immunity to cancer. Regulatory T (Treg) cells are known for their critical role in suppressing inflammation, and therefore can antagonize effective anti-cancer immune responses. As such, Treg cells can play detrimental roles in tumour progression and in the response to both conventional and immune-based cancer therapies. Recent advances in our understanding of Treg cells reveal complex niche-specific regulatory programmes and functions, which are likely to extrapolate to cancer. The regulation of Treg cells is reliant on upstream cues from haematopoietic and non-immune cells, which dictates their genetic, epigenetic and downstream functional programmes. In this review we will discuss how Treg cells are themselves regulated in normal and transformed tissues, and the implications of this cross talk on tumour growth.

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Keywords

cancer, chemokine/chemokine receptors, cytokines/cytokine receptors, regulatory T cells, tumour immunology, Animals, Humans, Inflammation Mediators, Lymphocytes, Tumor-Infiltrating, Neoplasms, Phenotype, Signal Transduction, T-Lymphocytes, Regulatory, Tumor Escape, Tumor Microenvironment

Journal Title

Immunology

Conference Name

Journal ISSN

0019-2805
1365-2567

Volume Title

157

Publisher

Wiley

Rights

All rights reserved
Sponsorship
Wellcome Trust (204622/Z/16/Z)
MRC (MR/S024468/2)
MRC (1947452)
Cancer Research UK (24995)