Mitochondrial respiration and dynamics of in vivo neural stem cells.


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Abstract

Neural stem cells (NSCs) in the developing and adult brain undergo many different transitions, tightly regulated by extrinsic and intrinsic factors. While the role of signalling pathways and transcription factors is well established, recent evidence has also highlighted mitochondria as central players in NSC behaviour and fate decisions. Many aspects of cellular metabolism and mitochondrial biology change during NSC transitions, interact with signalling pathways and affect the activity of chromatin-modifying enzymes. In this Spotlight, we explore recent in vivo findings, primarily from Drosophila and mammalian model systems, about the role that mitochondrial respiration and morphology play in NSC development and function.

Description

Peer reviewed: True


Funder: Indian Institutes of Science Education and Research Pune

Keywords
Mitochondria, Mitochondrial morphology, Neural stem cell, Notch, Oxidative phosphorylation, Reactive oxygen species, Animals, Neural Stem Cells, Mitochondria, Respiration, Drosophila, Brain, Mammals
Journal Title
Development
Conference Name
Journal ISSN
0950-1991
1477-9129
Volume Title
Publisher
The Company of Biologists
Sponsorship
Evelyn Trust (21/25)
Wellcome Trust (219615/Z/19/Z)
MRC (MC_UU_00028/8)