Ligand-assisted palladium-catalyzed C–H alkenylation of aliphatic amines for the synthesis of functionalized pyrrolidines
Published version
Peer-reviewed
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Authors
He, C
Gaunt, MJ
Abstract
The development of a ligand-assisted Pd-catalyzed C–H alkenylation of aliphatic amines is reported. Our studies indicated that an amino-acid-derived ligand renders the C–H bond activation step reversible and promotes the traditionally difficult alkenylation process. The C(sp
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Keywords
0305 Organic Chemistry
Journal Title
Chemical Science
Conference Name
Journal ISSN
2041-6520
2041-6539
2041-6539
Volume Title
8
Publisher
Royal Society of Chemistry
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Sponsorship
Engineering and Physical Sciences Research Council (EP/I00548X/1)
European Research Council (259711)
European Commission (656812)
European Research Council (259711)
European Commission (656812)
We are grateful to EPSRC (EP/100548X/1 for C. H. & M. J. G.), ERC (ERC-STG-259711 to M. J. G.) and the Marie Curie Foundation (C. H.) for funding.