Integrated functional genomic screening to bypass TKI resistance in chronic myeloid leukemia.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Beinortas, Tumas
Huntly, Brian JP
Abstract
CML is readily treatable with tyrosine kinase inhibitors (TKIs); however, resistance occurs, with the disease curable in only ∼15%-20% of patients. Using integrated functional genomics, Adnan Awad et al.1 identify agents effective against CML stem cells and describe mechanisms underlying TKI resistance.
Description
Keywords
Humans, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Protein Kinase Inhibitors, Drug Resistance, Neoplasm, Genomics
Journal Title
Cell Rep Med
Conference Name
Journal ISSN
2666-3791
2666-3791
2666-3791
Volume Title
5
Publisher
Elsevier BV
