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Exploring in the classroom the relationship between alcohol intake and behavioral disorders through an animal model.

Published version
Peer-reviewed

Repository DOI


Change log

Authors

Hernández-García, Samanta  ORCID logo  https://orcid.org/0000-0002-6944-0050
Guerrero-Rubio, M Alejandra  ORCID logo  https://orcid.org/0000-0002-3261-2058
Henarejos-Escudero, Paula  ORCID logo  https://orcid.org/0000-0003-4295-2459
Martínez-Rodríguez, Pedro  ORCID logo  https://orcid.org/0000-0003-1682-5536
Gandía-Herrero, Fernando  ORCID logo  https://orcid.org/0000-0003-4389-3454

Abstract

Alcohol consumption has profound effects on behavior, such as impaired judgment, addiction or even death. It is estimated that alcohol contributes to around three million deaths worldwide, 13.5% of them in young people with ages between 20 and 39 years. Consequently, it is necessary to raise awareness among college and high school students of the risk related to alcohol drinking. The small nematode Caenorhabditis elegans is an animal widely used as a model organism to study nearly all aspects of Biochemistry. It is a powerful tool to test the potential bioactivity and molecular mechanisms of natural compounds and drugs in vivo. Therefore, it is an interesting topic to include in an undergraduate course of Biotechnology, Biochemistry or Biology students among other scientific vocations. C. elegans is also used as a neurobiological model to evaluate substances' neurotoxicity and behavioral effects. The proposed experiment introduces students to the handling of this preclinical model and to the evaluation of behavioral alterations induced by chemicals in scientific research. The effects of different doses of ethanol on C. elegans behavior are studied using a versatile chemotaxis assay. This laboratory experiment is suitable for an undergraduate course. The practical session can be used in the global strategies of information and awareness of educational centres to mitigate the impact of alcohol abuse among students, both in formal courses or in Science fairs or exhibitions.

Description

Publication status: Published


Funder: Universidad de Murcia

Keywords

alcohol abuse, biotechnology, consumer chemistry, drugs/pharmaceuticals, hands‐on learning, laboratory instruction, scientific practice, toxicology, Animals, Caenorhabditis elegans, Alcohol Drinking, Humans, Students, Ethanol, Disease Models, Animal, Models, Animal, Behavior, Animal

Journal Title

Biochem Mol Biol Educ

Conference Name

Journal ISSN

1470-8175
1539-3429

Volume Title

Publisher

Wiley
Sponsorship
Ministerio de Ciencia e Innovación (PID2021‐122896NB‐I00)
Fundación Séneca (21587/FPI/21)