Repository logo
 

A spatial and temporal analysis of paediatric central nervous system infections from 2005 to 2015 in Ho Chi Minh City, Vietnam.

Accepted version
Peer-reviewed

No Thumbnail Available

Type

Article

Change log

Authors

Ho, NT 
Hoang, VMT 
Le, NNT 
Nguyen, DT 
Tran, A 

Abstract

Central nervous system infections (CNSI) are a leading cause of death and long-term disability in children. Using ICD-10 data from 2005 to 2015 from three central hospitals in Ho Chi Minh City (HCMC), Vietnam, we exploited generalized additive mixed models (GAMM) to examine the spatial-temporal distribution and spatial and climatic risk factors of paediatric CNSI, excluding tuberculous meningitis, in this setting. From 2005 to 2015, there were 9469 cases of paediatric CNSI; 33% were ⩽1 year old at admission and were mainly diagnosed with presumed bacterial CNSI (BI) (79%), the remainder were >1 year old and mainly diagnosed with presumed non-bacterial CNSI (non-BI) (59%). The urban districts of HCMC in proximity to the hospitals as well as some outer districts had the highest incidences of BI and non-BI; BI incidence was higher in the dry season. Monthly BI incidence exhibited a significant decreasing trend over the study. Both BI and non-BI were significantly associated with lags in monthly average temperature, rainfall, and river water level. Our findings add new insights into this important group of infections in Vietnam, and highlight where resources for the prevention and control of paediatric CNSI should be allocated.

Description

Keywords

Encephalitis, epidemiology, meningitis, paediatric, spatial temporal, Adolescent, Central Nervous System Infections, Child, Child, Preschool, Encephalitis, Viral, Female, Humans, Incidence, Infant, Male, Meningitis, Bacterial, Meningitis, Viral, Risk Factors, Seasons, Spatio-Temporal Analysis, Urban Population, Vietnam

Journal Title

Epidemiology and Infection

Conference Name

Journal ISSN

0950-2688
1469-4409

Volume Title

145

Publisher

Cambridge University Press
Sponsorship
This work was funded by the Wellcome Trust. SB is a Sir Henry Dale Fellow, jointly funded by the Wellcome Trust and the Royal Society (100087/Z/12/Z). NTH is currently funded by a Mervyn Susser Fellowship at Columbia University Medical Center, USA