Zinc delivery from non-woven fibres within a therapeutic nipple shield.


Change log
Authors
Maier, Theresa 
Scheuerle, Rebekah L 
Bruggraber, Sylvaine 
Abstract

A Therapeutic Nipple Shield (TNS) was previously developed to respond to the global need for new infant therapeutic delivery technologies. However, the release efficiency for the same Active Pharmaceutical Ingredient (API) from different therapeutic matrices within the TNS formulation has not yet been investigated. To address this, in-vitro release of elemental zinc into human milk from two types of Texel non-woven fibre mats of varying thickness and different gram per square meter values, placed inside the TNS was explored and compared to the release from zinc-containing rapidly disintegrating tablets. In-vitro delivery was performed by means of a breastfeeding simulation apparatus, with human milk flow rates and suction pressure adjusted to physiologically relevant values, and release was quantified using Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES). It was found that a total recovery of 62-64 % elemental zinc was obtained after the human milk had passed through the fibre insert, amounting to a 20-48% increase compared to previous zinc delivery studies using rapidly disintegrating tablets within the TNS. This indicates that non-woven Texel fibre mats were identified as the superior dosage form for oral zinc delivery into human milk using a TNS.

Description
Keywords
Breastfeeding, Human milk, Medication systems, Oral delivery, Pediatrics, X-ray micro computed tomography, Breast Feeding, Chemistry, Pharmaceutical, Drug Delivery Systems, Female, Humans, Infant, Milk, Human, Nipples, Tablets, Zinc
Journal Title
Int J Pharm
Conference Name
Journal ISSN
0378-5173
1873-3476
Volume Title
537
Publisher
Elsevier BV
Sponsorship
Grand Challenges Canada (0454-03-40)