Repository logo

Down syndrome is associated with increased risk for in-hospital mortality and morbidity in children and adolescents with SARS-CoV-2 in Brazil

Accepted version

Change log


Down syndrome (DS) is the most common chromosomal disorder. It is not clear if it is a risk factor for COVID-19 mortality and morbidity in pediatric patients, those in low-to-middle income countries in particular. Data of participants aged below 18 years with SARS-CoV-2 infection were gathered from a national registry in Brazil.

A total of 14,684 hospitalized patients were included, including 261 patients with DS. After adjusted for sociodemographic and medical factors, participants with DS had 1.8 times higher odds of dying from COVID-19 (OR 1.82, 95% CI 1.22-2.68) and had 27% longer time to recovery (HR 0.73, 95% CI 0.61-0.86). Down syndrome was found to be associated with increased risk for mortality and morbidity. The increased risk of death among people with DS may be due to social factors and biological factors such as immune responses.



Journal Title

Emerging Infectious Diseases

Conference Name

Journal ISSN


Volume Title


U.S. National Center for Infectious Diseases

Publisher DOI

Publisher URL

Not Funded