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Bioprinting of three-dimensional culture models and organ-on-a-chip systems

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Huang, YYS 
Zhang, D 
Liu, Y 

Abstract

Multimaterial bioprinting technologies offer promising avenues to create mini-organ models with enhanced tissue heterogeneity and complexity. This article focuses on the application of three-dimensional bioprinting to fabricate organ-on-a-chip systems for in vitro drug testing and screening. We illustrate the capabilities and limitations of a bioprinting approach compared to microfabrication in constructing an organ-on-a-chip device. Further, we propose strategies in multimaterial integration for printing microphysiological tissue models. With these analyses, key challenges and future directions are highlighted.

Description

Keywords

40 Engineering, 4003 Biomedical Engineering, Biotechnology, Bioengineering, Generic health relevance

Journal Title

MRS Bulletin

Conference Name

Journal ISSN

0883-7694
1938-1425

Volume Title

42

Publisher

Materials Research Society
Sponsorship
Engineering and Physical Sciences Research Council (EP/M018989/1)
D.Z. gratefully acknowledges support from the China Scholarship Council. Y.L. acknowledges the Schlumberger Foundation and Trinity College Cambridge. Y.Y.S.H. thanks EPSRC, the Royal Society London, and the Isaac Newton Trust for funding support.