Making biological knowledge useful for humans and machines.
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Standardized nomenclature for genes, gene products and isoforms is crucial to prevent ambiguity and enable clear communication of scientific data, facilitating efficient biocuration and data sharing. Standardized genotype nomenclature, which describes alleles present in a specific strain that differ from the wild-type reference strain, is equally essential to maximize research impact and ensure that results linking genotypes to phenotypes are FAIR (Findable, Accessible, Interoperable, and Reusable). In this publication, we extend the fission yeast clade gene nomenclature guidelines to support the curation efforts at PomBase (www.pombase.org), the Schizosaccahromyces pombe Model Organism Database. This update introduces nomenclature guidelines for non-coding RNA genes, following those set forth by the HUGO Gene Nomenclature Committee. Additionally, we provide a significant update to the allele and
genotype nomenclature guidelines originally published in 1987, to standardize the diverse range of genetic modifications enabled by the fission yeast genetic toolbox. These updated guidelines reflect a community consensus between numerous fission yeast researchers. Adoption of these rules will improve consistency in gene and genotype nomenclature, and facilitate machine-readability and automated entity recognition of fission yeast genes and alleles in publications or datasets. In conclusion, our updated guidelines provide a valuable resource for the fission yeast research community, promoting consistency, clarity, and FAIRness in genetic data sharing and interpretation.
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1943-2631