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Ancient DNA reveals evolutionary origins of autoimmune diseases.

Accepted version
Peer-reviewed

Repository URI

https://www.repository.cam.ac.uk/handle/1810/396954

Repository DOI

https://doi.org/10.17863/CAM.126178
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Primary Accepted version (53.48 KB)

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Article

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Authors

Irving-Pease, Evan K  ORCID logo  https://orcid.org/0000-0003-1940-2192
Fugger, Lars  ORCID logo  https://orcid.org/0000-0003-2883-3226

Abstract

Most autoimmune diseases are caused by the interplay between common genetic risk variants and environmental factors. New studies of ancient genomes suggest that many of these variants evolved under strong selection pressures, probably due to lifestyle-specific environmental pathogens, the consequences of which shape the distribution of present-day disease risk and point to novel therapeutic interventions.

Description

Keywords

Humans, DNA, Ancient, Biological Evolution, Evolution, Molecular, Autoimmune Diseases

Journal Title

Nat Rev Immunol

Conference Name

Journal ISSN

1474-1733
1474-1741

Volume Title

24

Publisher

Springer Nature

Publisher DOI

https://doi.org/10.1038/s41577-023-00983-6

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All Rights Reserved
Except where otherwised noted, this item's license is described as All Rights Reserved
Sponsorship
Medical Research Council

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University of Cambridge Research Outputs (Articles and Conferences)