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Reaction Time and Visual Memory in Connection with Alcohol Use in Schizophrenia and Schizoaffective Disorder

Published version
Peer-reviewed

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Authors

Mazumder, Atiqul Haq  ORCID logo  https://orcid.org/0000-0002-2148-4070
Barnett, Jennifer 
Lindberg, Nina 
Torniainen-Holm, Minna  ORCID logo  https://orcid.org/0000-0003-2149-855X
Lähteenvuo, Markku  ORCID logo  https://orcid.org/0000-0002-7244-145X

Abstract

The purpose of this study was to explore the association between cognition and hazardous drinking and alcohol use disorder in schizophrenia and schizoaffective disorder. Cognition is more or less compromised in schizophrenia, and schizoaffective disorder and alcohol use might aggravate this phenomenon. The study population included 3362 individuals from Finland with diagnoses of schizophrenia or schizoaffective disorder. Hazardous drinking was screened with the AUDIT-C (Alcohol Use Disorders Identification Test for Consumption) screening tool. Alcohol use disorder (AUD) diagnoses were obtained from national registrar data. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: The Five-Choice Serial Reaction Time Task (5-CSRTT) or the reaction time (RT) test and the Paired Associative Learning (PAL) test. The association between alcohol use and the RT and PAL tests was analyzed with log-linear regression and logistic regression, respectively. After adjustment for age, education, housing status, and the age at which the respondents had their first psychotic episodes, hazardous drinking was associated with a lower median RT in females and less variable RT in males, while AUD was associated with a poorer PAL test performance in terms of the total errors adjusted scores (TEASs) in females. Our findings of positive associations between alcohol and cognition in schizophrenia and schizoaffective disorder are unique.

Description

Keywords

cognition, visual memory, reaction time, alcohol, schizophrenia, schizoaffective disorder

Journal Title

Brain Sciences

Conference Name

Journal ISSN

2076-3425

Volume Title

11

Publisher

MDPI
Sponsorship
Stanley Center for Psychiatric Research, Broad Institute (0000-0000)
H2020 Marie Skłodowska-Curie Actions (713606)
Iso-Mällisen Foundation (Iso-Mällisen Säätiö) (0400 584622)