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The cellular composition of the human immune system is shaped by age and cohabitation.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Carr, Edward J 
Garcia-Perez, Josselyn E 
Lagou, Vasiliki 
Lee, James C 

Abstract

Detailed population-level description of the human immune system has recently become achievable. We used a 'systems-level' approach to establish a resource of cellular immune profiles of 670 healthy individuals. We report a high level of interindividual variation, with low longitudinal variation, at the level of cellular subset composition of the immune system. Despite the profound effects of antigen exposure on individual antigen-specific clones, the cellular subset structure proved highly elastic, with transient vaccination-induced changes followed by a return to the individual's unique baseline. Notably, the largest influence on immunological variation identified was cohabitation, with 50% less immunological variation between individuals who share an environment (as parents) than between people in the wider population. These results identify local environmental conditions as a key factor in shaping the human immune system.

Description

Keywords

Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Aging, Antigens, Child, Child, Preschool, Environment, Environmental Exposure, Female, Homeostasis, Humans, Immune System, Influenza Vaccines, Leukocytes, Male, Middle Aged, Residence Characteristics, Systems Analysis, Young Adult

Journal Title

Nat Immunol

Conference Name

Journal ISSN

1529-2908
1529-2916

Volume Title

17

Publisher

Springer Science and Business Media LLC

Rights

All rights reserved
Sponsorship
Wellcome Trust (105920/Z/14/Z)