Stem Cell-Derived Dopamine Neurons: Will They Replace DBS as the Leading Neurosurgical Treatment for Parkinson's Disease?
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Barker, Roger A
Björklund, Anders
Frucht, Steven J
Svendsen, Clive N
Abstract
The use of stem cell-derived dopamine neurons or deep brain stimulation (DBS) represents two alternative approaches to treat Parkinson's Disease. DBS is a widely used FDA-approved treatment and stem cell-derived dopamine neuron replacement has now evolved to the first in-human clinical trials. In this debate, we discuss which of these approaches will evolve to be the treatment of choice for Parkinsonian patients in the future.
Description
Keywords
DBS, Stem cells, brain repair, dopamine neurons, Deep Brain Stimulation, Dopaminergic Neurons, Humans, Neurosurgical Procedures, Parkinson Disease, Stem Cells
Journal Title
J Parkinsons Dis
Conference Name
Journal ISSN
1877-7171
1877-718X
1877-718X
Volume Title
11
Publisher
IOS Press
Publisher DOI
Rights
All rights reserved
Sponsorship
Medical Research Council (MC_PC_17230)