Cholesterol fuels microglia in chronic stroke.

Cholesterol fuels microglia in chronic stroke.

Accepted version

Peer-reviewed

Repository URI

https://www.repository.cam.ac.uk/handle/1810/394268

Repository DOI

https://doi.org/10.17863/CAM.124312

Files

Primary Accepted version (163.79 KB) (Embargoed until: 2026-03-23)

Supporting information (2.02 MB) (Embargoed until: 2026-03-23)

Type

Authors

Pluchino, Stefano

https://orcid.org/0000-0002-6267-9472

Willis, Cory M

https://orcid.org/0000-0001-7938-7276

Abstract

Cholesterol accumulation in microglia drives persistent inflammation after stroke. In this issue of Nature Metabolism, Zhao et al. suggest that enhancing microglial cholesterol catabolism may offer a promising strategy to reduce brain damage and improve recovery.

Keywords

3205 Medical Biochemistry and Metabolomics, 3208 Medical Physiology, 32 Biomedical and Clinical Sciences, 3210 Nutrition and Dietetics, Brain Disorders, Neurosciences, Cerebrovascular, Stroke, Aging, 2.1 Biological and endogenous factors, Stroke, Neurological

Journal Title

Nat Metab

Journal ISSN

2522-5812
2522-5812

Volume Title

7

Publisher

Springer Nature

Publisher DOI

https://doi.org/10.1038/s42255-025-01362-2

Rights and licensing

All Rights Reserved

Except where otherwised noted, this item's license is described as All Rights Reserved

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University of Cambridge Research Outputs (Articles and Conferences)