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The genetics of obesity: from discovery to biology.

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The prevalence of obesity has tripled over the past four decades, imposing an enormous burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset monogenic obesity are often polarized as distinct diseases. However, gene discovery studies for both forms of obesity show that they have shared genetic and biological underpinnings, pointing to a key role for the brain in the control of body weight. Genome-wide association studies (GWAS) with increasing sample sizes and advances in sequencing technology are the main drivers behind a recent flurry of new discoveries. However, it is the post-GWAS, cross-disciplinary collaborations, which combine new omics technologies and analytical approaches, that have started to facilitate translation of genetic loci into meaningful biology and new avenues for treatment.



Animals, Eating, Gene-Environment Interaction, Genetic Predisposition to Disease, Genetic Variation, Genome, Human, Genome-Wide Association Study, Humans, Multifactorial Inheritance, Obesity, Overweight, Whole Genome Sequencing

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Nat Rev Genet

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Springer Science and Business Media LLC
MRC (MC_UU_00014/1)
Medical Research Council (MC_UU_12012/1)
Medical Research Council (MC_UU_12012/5)
MRC (MR/S026193/1)
MRC (MC_UU_00014/5)
Biotechnology and Biological Sciences Research Council (BB/S017593/1)
Medical Research Council (MC_PC_12012)