Alterations in white matter microstructure in alcohol and alcohol‐polydrug dependence: Associations with lifetime alcohol and nicotine exposure
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Peer-reviewed
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Abstract
Alcohol‐dependent participants showed lower fractional anisotropy (FA) within the corpus callosum compared with healthy controls. This change was negatively associated with lifetime alcohol and nicotine exposure, and there was no evidence of FA recovery despite prolonged abstinence. A group‐by‐age interaction was observed, whereby greater age‐related reductions in FA were evident in AD participants, but no further reductions in FA were observed in alcohol‐polysubstance relative to alcohol‐only‐dependent participants.
Description
Funder: GlaxoSmithKline; Id: http://dx.doi.org/10.13039/100004330
Keywords
5202 Biological Psychology, 3214 Pharmacology and Pharmaceutical Sciences, 32 Biomedical and Clinical Sciences, 52 Psychology, Tobacco, Neurosciences, Substance Misuse, Alcoholism, Alcohol Use and Health, Brain Disorders, Clinical Research, 3.1 Primary prevention interventions to modify behaviours or promote wellbeing, 2.1 Biological and endogenous factors, Cancer, Mental health, 3 Good Health and Well Being
Journal Title
Addiction Biology
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Journal ISSN
1355-6215
1369-1600
1369-1600
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Publisher
Wiley
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Except where otherwised noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/
Sponsorship
Medical Research Council (G1000018/1)