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Therapeutic Avenues to Modulate B-Cell Function in Patients With Cardiovascular Disease.

Accepted version
Peer-reviewed

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Authors

Abstract

The adaptive immune system plays an important role in the development and progression of atherosclerotic cardiovascular disease. B cells can have both proatherogenic and atheroprotective roles, making treatments aimed at modulating B cells important therapeutic targets. The innate-like B-cell response is generally considered atheroprotective, while the adaptive response is associated with mixed consequences for atherosclerosis. Additionally, interactions of B cells with components of the adaptive and innate immune system, including T cells and complement, also represent key points for therapeutic regulation. In this review, we discuss therapeutic approaches based on B-cell depletion, modulation of B-cell survival, manipulation of both the antibody-dependent and antibody-independent B-cell response, and emerging immunization techniques.

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Keywords

T-lymphocytes, atherosclerosis, cardiovascular diseases, cell survival, immunization

Journal Title

Arterioscler Thromb Vasc Biol

Conference Name

Journal ISSN

1079-5642
1524-4636

Volume Title

Publisher

Ovid Technologies (Wolters Kluwer Health)
Sponsorship
British Heart Foundation (CH/10/001/27642)
British Heart Foundation (PG/23/11508)
Heart Research UK (RG2699/21/23)
Leducq Foundation For Cardiovascular Research (20CVD03)