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Analysis of relative changes in pulse shapes of intracranial pressure and cerebral blood flow velocity.

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cam.issuedOnline2021-12-29
dc.contributor.authorZiółkowski, Arkadiusz
dc.contributor.authorPudełko, Agata
dc.contributor.authorKazimierska, Agnieszka
dc.contributor.authorCzosnyka, Zofia
dc.contributor.authorCzosnyka, Marek
dc.contributor.authorKasprowicz, Magdalena
dc.contributor.orcidZiółkowski, Arkadiusz [0000-0002-2630-514X]
dc.contributor.orcidPudełko, Agata [0000-0001-7692-6422]
dc.contributor.orcidKazimierska, Agnieszka [0000-0002-6227-9452]
dc.contributor.orcidKasprowicz, Magdalena [0000-0002-2271-7737]
dc.date.accessioned2022-01-07T16:49:35Z
dc.date.available2022-01-07T16:49:35Z
dc.date.issued2021-12-29
dc.date.submitted2021-06-29
dc.date.updated2022-01-07T16:49:34Z
dc.description.abstractObjective.Analysis of relative changes in the shapes of pulse waveforms of intracranial pressure (ICP) and transcranial Doppler cerebral blood flow velocity (CBFV) may provide information on intracranial compliance. We tested this hypothesis, introducing an index named the ratio of pulse slopes (RPS) that is based on inclinations of the ascending parts of the ICP and CBFV pulse waveforms. It has hypothetically a simple interpretation: a value of 1 indicates good compliance and a value less than 1, reduced compliance. Here, we investigated the usefulness of RPS for assessment of intracranial compliance.Approach.ICP and CBFV signals recorded simultaneously in 30 normal-pressure hydrocephalus patients during infusion tests were retrospectively analysed. CBFV was measured in the middle cerebral artery. Changes in RPS during the test were compared with changes in the height ratio of the first and second peak of the ICP pulse (P1/P2) and the shape of the ICP pulse was classified from normal (1) to pathological (4). Values are medians (lower, upper quartiles).Main results.There was a significant correlation between baseline RPS and intracranial elasticity (R = -0.55,p = 0.0018). During the infusion tests, both RPS and P1/P2 decreased with rising ICP [RPS, 0.80 (0.56, 0.92) versus 0.63 (0.44, 0.80),p = 0.00015; P1/P2, 0.58 (0.50, 0.91) versus 0.52 (0.36, 0.71),p = 0.00009] while the ICP pulses became more pathological in shape [class: 3 (2, 3) versus 3 (3, 4),p = 0.04]. The magnitude of the decrease in RPS during infusion was inversely correlated with baseline P1/P2 (R = -0.40,p < 0.03).Significance.During infusion, the slopes of the ascending parts of ICP and CBFV pulses become increasingly divergent with a shift in opposite directions. RPS seems to be a promising methodological tool for monitoring intracranial compliance with no additional volumetric manipulation required.
dc.identifier.doi10.17863/CAM.79814
dc.identifier.eissn1361-6579
dc.identifier.issn0967-3334
dc.identifier.otherpmeaac38bf
dc.identifier.otherac38bf
dc.identifier.otherpmea-104300.r2
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332368
dc.languageen
dc.language.isoeng
dc.publisherIOP Publishing
dc.publisher.urlhttp://dx.doi.org/10.1088/1361-6579/ac38bf
dc.subjectcerebral blood flow
dc.subjecthydrocephalus
dc.subjectintracranial compliance
dc.subjectintracranial pressure
dc.subjectmorphological analysis
dc.subjecttranscranial Doppler
dc.subjectBlood Flow Velocity
dc.subjectBlood Pressure
dc.subjectCerebrovascular Circulation
dc.subjectHumans
dc.subjectIntracranial Pressure
dc.subjectRetrospective Studies
dc.subjectUltrasonography, Doppler, Transcranial
dc.titleAnalysis of relative changes in pulse shapes of intracranial pressure and cerebral blood flow velocity.
dc.typeArticle
dcterms.dateAccepted2021-11-11
prism.issueIdentifier12
prism.publicationNamePhysiol Meas
prism.volume42
pubs.funder-project-idPolish National Agency for Academic Exchange (International Academic Partnerships (AK))
pubs.funder-project-idNational Science Centre, Poland (UMO2019/35/B/ST7/00500 (MK))
pubs.funder-project-idEuropean Regional Development Fund (Revert Project, Interreg France (Channel Manche) England (MC, ZC))
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1088/1361-6579/ac38bf

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