Imaging biomarkers in neurodegeneration: current and future practices.


Type
Article
Change log
Authors
Young, Peter NE 
Estarellas, Mar 
Coomans, Emma 
Srikrishna, Meera 
Beaumont, Helen 
Abstract

There is an increasing role for biological markers (biomarkers) in the understanding and diagnosis of neurodegenerative disorders. The application of imaging biomarkers specifically for the in vivo investigation of neurodegenerative disorders has increased substantially over the past decades and continues to provide further benefits both to the diagnosis and understanding of these diseases. This review forms part of a series of articles which stem from the University College London/University of Gothenburg course "Biomarkers in neurodegenerative diseases". In this review, we focus on neuroimaging, specifically positron emission tomography (PET) and magnetic resonance imaging (MRI), giving an overview of the current established practices clinically and in research as well as new techniques being developed. We will also discuss the use of machine learning (ML) techniques within these fields to provide additional insights to early diagnosis and multimodal analysis.

Description
Keywords
Alzheimer’s disease, MRI, Machine learning, Neurodegenerative diseases, Neuroimaging, PET, dementia, Alzheimer Disease, Biomarkers, Humans, Magnetic Resonance Imaging, Neuroimaging, Positron-Emission Tomography
Journal Title
Alzheimers Res Ther
Conference Name
Journal ISSN
1758-9193
1758-9193
Volume Title
12
Publisher
Springer Science and Business Media LLC