The Y Chromosome: A Complex Locus for Genetic Analyses of Complex Human Traits.


Change log
Authors
Parker, Katherine 
Erzurumluoglu, A Mesut  ORCID logo  https://orcid.org/0000-0003-1322-8138
Rodriguez, Santiago  ORCID logo  https://orcid.org/0000-0001-6551-932X
Abstract

The Human Y chromosome (ChrY) has been demonstrated to be a powerful tool for phylogenetics, population genetics, genetic genealogy and forensics. However, the importance of ChrY genetic variation in relation to human complex traits is less clear. In this review, we summarise existing evidence about the inherent complexities of ChrY variation and their use in association studies of human complex traits. We present and discuss the specific particularities of ChrY genetic variation, including Y chromosomal haplogroups, that need to be considered in the design and interpretation of genetic epidemiological studies involving ChrY.

Description
Keywords
Y chromosome, Y haplogroups, complex human traits, complex locus, genetic association analyses, genetic epidemiology, Chromosomes, Human, Y, Genetic Association Studies, Genetic Variation, Genetics, Population, Genome-Wide Association Study, Haplotypes, Humans, Male, Models, Genetic, Molecular Epidemiology, Multifactorial Inheritance, Quantitative Trait Loci, Recombination, Genetic, Sex Determination Processes
Journal Title
Genes (Basel)
Conference Name
Journal ISSN
2073-4425
2073-4425
Volume Title
11
Publisher
MDPI AG
Sponsorship
Medical Research Council (MC_UU_12015/1)
MRC (MC_UU_00006/1)