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SARS-CoV-2 and innate immunity: the good, the bad, and the "goldilocks".

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Peer-reviewed

Repository URI

https://www.repository.cam.ac.uk/handle/1810/364017

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Primary Published version (1.38 MB)
 Bibliographic metadata (298.03 KB)

Type

Article

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Authors

Sievers, Benjamin L  ORCID logo  https://orcid.org/0000-0002-9681-9082
Cheng, Mark TK  ORCID logo  https://orcid.org/0000-0003-4323-5574
Gupta, Ravindra K  ORCID logo  https://orcid.org/0000-0001-9751-1808

Abstract

An ancient conflict between hosts and pathogens has driven the innate and adaptive arms of immunity. Knowledge about this interplay can not only help us identify biological mechanisms but also reveal pathogen vulnerabilities that can be leveraged therapeutically. The humoral response to SARS-CoV-2 infection has been the focus of intense research, and the role of the innate immune system has received significantly less attention. Here, we review current knowledge of the innate immune response to SARS-CoV-2 infection and the various means SARS-CoV-2 employs to evade innate defense systems. We also consider the role of innate immunity in SARS-CoV-2 vaccines and in the phenomenon of long COVID.

Description

Keywords

Antiviral targets, Cytokines, Inflammation, Innate immune response, Interferon, SARS-CoV-2, Humans, SARS-CoV-2, COVID-19, COVID-19 Vaccines, Post-Acute COVID-19 Syndrome, Immunity, Innate

Journal Title

Cell Mol Immunol

Conference Name

Journal ISSN

1672-7681
2042-0226

Volume Title

21

Publisher

Springer Nature

Publisher DOI

https://doi.org/10.1038/s41423-023-01104-y

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Attribution 4.0 International
Except where otherwised noted, this item's license is described as Attribution 4.0 International

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