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Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex.

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cam.issuedOnline2022-05-09
dc.contributor.authorValk, Sofie L
dc.contributor.authorXu, Ting
dc.contributor.authorPaquola, Casey
dc.contributor.authorPark, Bo-Yong
dc.contributor.authorBethlehem, Richard AI
dc.contributor.authorVos de Wael, Reinder
dc.contributor.authorRoyer, Jessica
dc.contributor.authorMasouleh, Shahrzad Kharabian
dc.contributor.authorBayrak, Şeyma
dc.contributor.authorKochunov, Peter
dc.contributor.authorYeo, BT Thomas
dc.contributor.authorMargulies, Daniel
dc.contributor.authorSmallwood, Jonathan
dc.contributor.authorEickhoff, Simon B
dc.contributor.authorBernhardt, Boris C
dc.contributor.orcidValk, Sofie L [0000-0003-2998-6849]
dc.contributor.orcidXu, Ting [0000-0002-0065-3832]
dc.contributor.orcidPark, Bo-Yong [0000-0001-7096-337X]
dc.contributor.orcidRoyer, Jessica [0000-0002-4448-8998]
dc.contributor.orcidMasouleh, Shahrzad Kharabian [0000-0003-4810-9542]
dc.contributor.orcidMargulies, Daniel [0000-0002-8880-9204]
dc.contributor.orcidBernhardt, Boris C [0000-0001-9256-6041]
dc.date.accessioned2022-06-10T01:06:07Z
dc.date.available2022-06-10T01:06:07Z
dc.date.issued2022-05-09
dc.date.updated2022-06-10T01:06:07Z
dc.description.abstractBrain structure scaffolds intrinsic function, supporting cognition and ultimately behavioral flexibility. However, it remains unclear how a static, genetically controlled architecture supports flexible cognition and behavior. Here, we synthesize genetic, phylogenetic and cognitive analyses to understand how the macroscale organization of structure-function coupling across the cortex can inform its role in cognition. In humans, structure-function coupling was highest in regions of unimodal cortex and lowest in transmodal cortex, a pattern that was mirrored by a reduced alignment with heritable connectivity profiles. Structure-function uncoupling in macaques had a similar spatial distribution, but we observed an increased coupling between structure and function in association cortices relative to humans. Meta-analysis suggested regions with the least genetic control (low heritable correspondence and different across primates) are linked to social-cognition and autobiographical memory. Our findings suggest that genetic and evolutionary uncoupling of structure and function in different transmodal systems may support the emergence of complex forms of cognition.
dc.identifier.doi10.17863/CAM.85384
dc.identifier.eissn2041-1723
dc.identifier.issn2041-1723
dc.identifier.other35534454
dc.identifier.otherPMC9085871
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337978
dc.languageeng
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.publisher.urlhttp://dx.doi.org/10.1038/s41467-022-29886-1
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcenlmid: 101528555
dc.sourceessn: 2041-1723
dc.subjectAnimals
dc.subjectBrain
dc.subjectBrain Mapping
dc.subjectCerebral Cortex
dc.subjectCognition
dc.subjectHumans
dc.subjectMagnetic Resonance Imaging
dc.subjectPhylogeny
dc.titleGenetic and phylogenetic uncoupling of structure and function in human transmodal cortex.
dc.typeArticle
dcterms.dateAccepted2022-04-01
prism.issueIdentifier1
prism.publicationNameNat Commun
prism.volume13
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1038/s41467-022-29886-1

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