Repository logo
 

Ancient origins of low lean mass among South Asians and implications for modern type 2 diabetes susceptibility

Published version
Peer-reviewed

Change log

Authors

Mushrif-Tripathy, Veena  ORCID logo  https://orcid.org/0000-0002-4749-1316
Wells, Jonathan C. K. 
Stock, Jay T. 

Abstract

Abstract: Living South Asians have low lean tissue mass relative to height, which contributes to their elevated type 2 diabetes susceptibility, particularly when accompanied by obesity. While ongoing lifestyle transitions account for rising obesity, the origins of low lean mass remain unclear. We analysed proxies for lean mass and stature among South Asian skeletons spanning the last 11,000 years (n = 197) to investigate the origins of South Asian low lean mass. Compared with a worldwide sample (n = 2,003), South Asian skeletons indicate low lean mass. Stature-adjusted lean mass increased significantly over time in South Asia, but to a very minor extent (0.04 z-score units per 1,000 years, adjusted R2 = 0.01). In contrast stature decreased sharply when agriculture was adopted. Our results indicate that low lean mass has characterised South Asians since at least the early Holocene and may represent long-term climatic adaptation or neutral variation. This phenotype is therefore unlikely to change extensively in the short term, so other strategies to address increasing non-communicable disease rates must be pursued.

Description

Keywords

Article, /631/181/19/2471, /692/699/2743/137/773, article

Journal Title

Scientific Reports

Conference Name

Journal ISSN

2045-2322

Volume Title

9

Publisher

Nature Publishing Group UK