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Expression Atlas update: gene and protein expression in multiple species.

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cam.depositDate2022-02-10
cam.issuedOnline2021-11-24
dc.contributor.authorMoreno, Pablo
dc.contributor.authorFexova, Silvie
dc.contributor.authorGeorge, Nancy
dc.contributor.authorManning, Jonathan R
dc.contributor.authorMiao, Zhichiao
dc.contributor.authorMohammed, Suhaib
dc.contributor.authorMuñoz-Pomer, Alfonso
dc.contributor.authorFullgrabe, Anja
dc.contributor.authorBi, Yalan
dc.contributor.authorBush, Natassja
dc.contributor.authorIqbal, Haider
dc.contributor.authorKumbham, Upendra
dc.contributor.authorSolovyev, Andrey
dc.contributor.authorZhao, Lingyun
dc.contributor.authorPrakash, Ananth
dc.contributor.authorGarcía-Seisdedos, David
dc.contributor.authorKundu, Deepti J
dc.contributor.authorWang, Shengbo
dc.contributor.authorWalzer, Mathias
dc.contributor.authorClarke, Laura
dc.contributor.authorOsumi-Sutherland, David
dc.contributor.authorTello-Ruiz, Marcela Karey
dc.contributor.authorKumari, Sunita
dc.contributor.authorWare, Doreen
dc.contributor.authorEliasova, Jana
dc.contributor.authorArends, Mark J
dc.contributor.authorNawijn, Martijn C
dc.contributor.authorMeyer, Kerstin
dc.contributor.authorBurdett, Tony
dc.contributor.authorMarioni, John
dc.contributor.authorTeichmann, Sarah
dc.contributor.authorVizcaíno, Juan Antonio
dc.contributor.authorBrazma, Alvis
dc.contributor.authorPapatheodorou, Irene
dc.contributor.orcidMoreno, Pablo [0000-0002-9856-1679]
dc.contributor.orcidMiao, Zhichiao [0000-0002-5777-9815]
dc.contributor.orcidFullgrabe, Anja [0000-0002-8674-0039]
dc.contributor.orcidClarke, Laura [0000-0002-5989-6898]
dc.contributor.orcidTello-Ruiz, Marcela Karey [0000-0002-7499-5368]
dc.contributor.orcidBurdett, Tony [0000-0002-2513-5396]
dc.contributor.orcidMarioni, John [0000-0001-9092-0852]
dc.contributor.orcidVizcaíno, Juan Antonio [0000-0002-3905-4335]
dc.contributor.orcidPapatheodorou, Irene [0000-0001-7270-5470]
dc.date.accessioned2022-02-11T00:31:26Z
dc.date.available2022-02-11T00:31:26Z
dc.date.issued2022-01-07
dc.date.updated2022-02-10T10:54:55Z
dc.description.abstractThe EMBL-EBI Expression Atlas is an added value knowledge base that enables researchers to answer the question of where (tissue, organism part, developmental stage, cell type) and under which conditions (disease, treatment, gender, etc) a gene or protein of interest is expressed. Expression Atlas brings together data from >4500 expression studies from >65 different species, across different conditions and tissues. It makes these data freely available in an easy to visualise form, after expert curation to accurately represent the intended experimental design, re-analysed via standardised pipelines that rely on open-source community developed tools. Each study's metadata are annotated using ontologies. The data are re-analyzed with the aim of reproducing the original conclusions of the underlying experiments. Expression Atlas is currently divided into Bulk Expression Atlas and Single Cell Expression Atlas. Expression Atlas contains data from differential studies (microarray and bulk RNA-Seq) and baseline studies (bulk RNA-Seq and proteomics), whereas Single Cell Expression Atlas is currently dedicated to Single Cell RNA-Sequencing (scRNA-Seq) studies. The resource has been in continuous development since 2009 and it is available at https://www.ebi.ac.uk/gxa.
dc.format.mediumPrint
dc.identifier.doi10.17863/CAM.81297
dc.identifier.eissn1362-4962
dc.identifier.issn0305-1048
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/333881
dc.language.isoeng
dc.publisherOxford University Press (OUP)
dc.publisher.departmentCancer Research Uk Cambridge Institute
dc.publisher.departmentDepartment of Physics
dc.publisher.urlhttp://dx.doi.org/10.1093/nar/gkab1030
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectComputational Biology
dc.subjectDatabases, Genetic
dc.subjectGene Expression Profiling
dc.subjectHumans
dc.subjectProteins
dc.subjectProteomics
dc.subjectRNA-Seq
dc.subjectSequence Analysis, RNA
dc.subjectSingle-Cell Analysis
dc.subjectSoftware
dc.titleExpression Atlas update: gene and protein expression in multiple species.
dc.typeArticle
dcterms.dateAccepted2021-11-19
prism.endingPageD140
prism.issueIdentifierD1
prism.publicationDate2022
prism.publicationNameNucleic Acids Res
prism.startingPageD129
prism.volume50
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Societal Challenges (874656)
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
pubs.licence-identifierapollo-deposit-licence-2-1
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1093/nar/gkab1030

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