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Polygenic risks for joint developmental trajectories of internalizing and externalizing problems: findings from the ALSPAC cohort.

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cam.issuedOnline2021-12-02
dc.contributor.authorSpeyer, Lydia Gabriela
dc.contributor.authorNeaves, Samuel
dc.contributor.authorHall, Hildigunnur Anna
dc.contributor.authorHemani, Gibran
dc.contributor.authorLombardo, Michael Vincent
dc.contributor.authorMurray, Aja Louise
dc.contributor.authorAuyeung, Bonnie
dc.contributor.authorLuciano, Michelle
dc.contributor.orcidSpeyer, Lydia Gabriela [0000-0001-9071-4020]
dc.contributor.orcidHall, Hildigunnur Anna [0000-0001-8010-9687]
dc.date.accessioned2021-12-22T15:05:38Z
dc.date.available2021-12-22T15:05:38Z
dc.date.issued2022-08
dc.date.updated2021-12-22T15:05:37Z
dc.descriptionFunder: University of Bristol; Id: http://dx.doi.org/10.13039/501100000883
dc.descriptionFunder: Medical Research Council; Id: http://dx.doi.org/10.13039/501100000265
dc.descriptionFunder: University Of Edinburgh; Id: http://dx.doi.org/10.13039/501100000848
dc.description.abstractBACKGROUND: Joint developmental trajectories of internalizing and externalizing problems show considerable heterogeneity; however, this can be parsed into a small number of meaningful subgroups. Doing so offered insights into risk factors that lead to different patterns of internalizing/externalizing trajectories. However, despite both domains of problems showing strong heritability, no study has yet considered genetic risks as predictors of joint internalizing/externalizing problem trajectories. METHODS: Using parallel process latent class growth analysis, we estimated joint developmental trajectories of internalizing and externalizing difficulties assessed across ages 4 to 16 using the Strengths and Difficulties Questionnaire. Multinomial logistic regression was used to evaluate a range of demographic, perinatal, maternal mental health, and child and maternal polygenic predictors of group membership. Participants included 11,049 children taking part in the Avon Longitudinal Study of Parents and Children. Polygenic data were available for 7,127 children and 6,836 mothers. RESULTS: A 5-class model was judged optimal: Unaffected, Moderate Externalizing Symptoms, High Externalizing Symptoms, Moderate Internalizing and Externalizing Symptoms and High Internalizing and Externalizing Symptoms. Male sex, lower maternal age, maternal mental health problems, maternal smoking during pregnancy, higher child polygenic risk scores for ADHD and lower polygenic scores for IQ distinguished affected classes from the unaffected class. CONCLUSIONS: While affected classes could be relatively well separated from the unaffected class, phenotypic and polygenic predictors were limited in their ability to distinguish between different affected classes. Results thus add to existing evidence that internalizing and externalizing problems have mostly shared risk factors.
dc.identifier.doi10.17863/CAM.79139
dc.identifier.eissn1469-7610
dc.identifier.issn0021-9630
dc.identifier.otherjcpp13549
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331689
dc.languageen
dc.language.isoeng
dc.publisherWiley
dc.publisher.urlhttp://dx.doi.org/10.1111/jcpp.13549
dc.subjectALSPAC
dc.subjectJoint mental health trajectories
dc.subjectexternalizing
dc.subjectinternalizing
dc.subjectpolygenic risk
dc.subjectAdolescent
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectFemale
dc.subjectHumans
dc.subjectLongitudinal Studies
dc.subjectMale
dc.subjectMothers
dc.subjectMultifactorial Inheritance
dc.subjectPregnancy
dc.subjectRisk Factors
dc.subjectSmoking
dc.titlePolygenic risks for joint developmental trajectories of internalizing and externalizing problems: findings from the ALSPAC cohort.
dc.typeArticle
dcterms.dateAccepted2021-10-22
prism.publicationNameJ Child Psychol Psychiatry
pubs.funder-project-idBaily Thomas Charitable Fund (TRUST/VC/AC/SG/469207686)
pubs.funder-project-idWellcome (217065/Z/19/Z)
pubs.funder-project-idEconomic and Social Research Council (ES/N018877/1, ES/R500938/1)
pubs.funder-project-idHorizon 2020 Framework Programme (813546)
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1111/jcpp.13549

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