Can exenatide flatten the post-prandial glucose curve in type 1 diabetes?
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Peer-reviewed
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Abstract
Attainment of recommended glycaemic control for people with type 1 diabetes (T1D) is challenging and requires lifelong self-management with insulin therapy. Approaches to restore pancreatic beta-cell function to reverse T1D such as islet/pancreas transplant, immunomodulatory therapies and stem cell therapies have not yielded acceptable safety and/or efficacy outcomes (1). Management of T1D therefore focuses on intensive insulin therapy to achieve near normoglycaemia and avoid long-term micro- and microvasculature complications (2). Despite improvements in insulin analogues and advances in diabetes technologies, less than 30% of people with T1D reach recommended glycaemic targets (3). Intensive insulin therapy is associated with increased risk of hypoglycaemia and weight gain (4).
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2305-5847
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Wellcome Trust (100574/B/12/Z)
Helmsley Charitable Trust (#2016PG-T1D046)
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)