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Can exenatide flatten the post-prandial glucose curve in type 1 diabetes?

Published version
Peer-reviewed

Type

Article

Change log

Authors

Boughton, Charlotte K 

Abstract

Attainment of recommended glycaemic control for people with type 1 diabetes (T1D) is challenging and requires lifelong self-management with insulin therapy. Approaches to restore pancreatic beta-cell function to reverse T1D such as islet/pancreas transplant, immunomodulatory therapies and stem cell therapies have not yielded acceptable safety and/or efficacy outcomes (1). Management of T1D therefore focuses on intensive insulin therapy to achieve near normoglycaemia and avoid long-term micro- and microvasculature complications (2). Despite improvements in insulin analogues and advances in diabetes technologies, less than 30% of people with T1D reach recommended glycaemic targets (3). Intensive insulin therapy is associated with increased risk of hypoglycaemia and weight gain (4).

Description

Keywords

32 Biomedical and Clinical Sciences, 3202 Clinical Sciences, Diabetes, Metabolic and endocrine

Journal Title

Ann Transl Med

Conference Name

Journal ISSN

2305-5839
2305-5847

Volume Title

8

Publisher

AME Publishing Company
Sponsorship
European Commission Horizon 2020 (H2020) Societal Challenges (731560)
Wellcome Trust (100574/B/12/Z)
Helmsley Charitable Trust (#2016PG-T1D046)
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)