Social and emotional characteristics of girls and young women with DDX3X-associated intellectual disability: a descriptive and comparative study.
cam.issuedOnline | 2022-05-10 | |
dc.contributor.author | Ng-Cordell, Elise | |
dc.contributor.author | Kolesnik-Taylor, Anna | |
dc.contributor.author | O'Brien, Sinéad | |
dc.contributor.author | Astle, Duncan | |
dc.contributor.author | Scerif, Gaia | |
dc.contributor.author | Baker, Kate | |
dc.contributor.orcid | Ng-Cordell, Elise [0000-0002-4747-8138] | |
dc.contributor.orcid | Kolesnik-Taylor, Anna [0000-0002-1395-0377] | |
dc.contributor.orcid | O'Brien, Sinéad [0000-0003-1556-4047] | |
dc.contributor.orcid | Astle, Duncan [0000-0002-7042-5392] | |
dc.contributor.orcid | Scerif, Gaia [0000-0002-6371-8875] | |
dc.contributor.orcid | Baker, Kate [0000-0003-2986-0584] | |
dc.date.accessioned | 2022-06-10T01:05:56Z | |
dc.date.available | 2022-06-10T01:05:56Z | |
dc.date.issued | 2023-08 | |
dc.date.updated | 2022-06-10T01:05:56Z | |
dc.description.abstract | DDX3X variants are a common cause of intellectual disability (ID) in females, and have been associated with autism spectrum disorder and emotional-behavioural difficulties. In this study, we compared phenotypic data for 23 females with DDX3X variants, to 23 females with ID and other genetic diagnoses. We found a wide range of adaptive, social and emotional function within the DDX3X group. Autism characteristics did not differ between DDX3X and comparison groups, while levels of anxiety and self-injurious behaviour (SIB) were significantly higher in the DDX3X group. Within the DDX3X group, adaptive function, autism characteristics, anxiety and SIB scores were positively correlated, with evidence for group-specific associations with SIB. Future work is warranted to explore the multilevel mechanisms contributing to social and emotional development in individuals with DDX3X variants. | |
dc.identifier.doi | 10.17863/CAM.85380 | |
dc.identifier.eissn | 1573-3432 | |
dc.identifier.issn | 0162-3257 | |
dc.identifier.other | 35536379 | |
dc.identifier.other | PMC9087164 | |
dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/337974 | |
dc.language | eng | |
dc.publisher | Springer Science and Business Media LLC | |
dc.publisher.url | http://dx.doi.org/10.1007/s10803-022-05527-w | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | nlmid: 7904301 | |
dc.source | essn: 1573-3432 | |
dc.subject | Anxiety | |
dc.subject | Autism | |
dc.subject | DDX3X | |
dc.subject | Intellectual disability | |
dc.subject | Self-injurious behaviour | |
dc.subject | Humans | |
dc.subject | Female | |
dc.subject | Intellectual Disability | |
dc.subject | Autism Spectrum Disorder | |
dc.subject | Emotions | |
dc.subject | Anxiety | |
dc.subject | Autistic Disorder | |
dc.subject | DEAD-box RNA Helicases | |
dc.title | Social and emotional characteristics of girls and young women with DDX3X-associated intellectual disability: a descriptive and comparative study. | |
dc.type | Article | |
dcterms.dateAccepted | 2022-03-09 | |
prism.publicationName | J Autism Dev Disord | |
pubs.funder-project-id | Newlife – The Charity for Disabled Children (Newlife – The Charity for Disabled Children) | |
pubs.funder-project-id | Baily Thomas Charitable Fund (Baily Thomas Charitable Fund) | |
pubs.funder-project-id | Medical Research Council (G101400) | |
pubs.funder-project-id | Newlife - The Charity for Disabled Children (Newlife - The Charity for Disabled Children) | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0/ | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1007/s10803-022-05527-w |
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