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Social and emotional characteristics of girls and young women with DDX3X-associated intellectual disability: a descriptive and comparative study.

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cam.issuedOnline2022-05-10
dc.contributor.authorNg-Cordell, Elise
dc.contributor.authorKolesnik-Taylor, Anna
dc.contributor.authorO'Brien, Sinéad
dc.contributor.authorAstle, Duncan
dc.contributor.authorScerif, Gaia
dc.contributor.authorBaker, Kate
dc.contributor.orcidNg-Cordell, Elise [0000-0002-4747-8138]
dc.contributor.orcidKolesnik-Taylor, Anna [0000-0002-1395-0377]
dc.contributor.orcidO'Brien, Sinéad [0000-0003-1556-4047]
dc.contributor.orcidAstle, Duncan [0000-0002-7042-5392]
dc.contributor.orcidScerif, Gaia [0000-0002-6371-8875]
dc.contributor.orcidBaker, Kate [0000-0003-2986-0584]
dc.date.accessioned2022-06-10T01:05:56Z
dc.date.available2022-06-10T01:05:56Z
dc.date.issued2023-08
dc.date.updated2022-06-10T01:05:56Z
dc.description.abstractDDX3X variants are a common cause of intellectual disability (ID) in females, and have been associated with autism spectrum disorder and emotional-behavioural difficulties. In this study, we compared phenotypic data for 23 females with DDX3X variants, to 23 females with ID and other genetic diagnoses. We found a wide range of adaptive, social and emotional function within the DDX3X group. Autism characteristics did not differ between DDX3X and comparison groups, while levels of anxiety and self-injurious behaviour (SIB) were significantly higher in the DDX3X group. Within the DDX3X group, adaptive function, autism characteristics, anxiety and SIB scores were positively correlated, with evidence for group-specific associations with SIB. Future work is warranted to explore the multilevel mechanisms contributing to social and emotional development in individuals with DDX3X variants.
dc.identifier.doi10.17863/CAM.85380
dc.identifier.eissn1573-3432
dc.identifier.issn0162-3257
dc.identifier.other35536379
dc.identifier.otherPMC9087164
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337974
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.publisher.urlhttp://dx.doi.org/10.1007/s10803-022-05527-w
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcenlmid: 7904301
dc.sourceessn: 1573-3432
dc.subjectAnxiety
dc.subjectAutism
dc.subjectDDX3X
dc.subjectIntellectual disability
dc.subjectSelf-injurious behaviour
dc.subjectHumans
dc.subjectFemale
dc.subjectIntellectual Disability
dc.subjectAutism Spectrum Disorder
dc.subjectEmotions
dc.subjectAnxiety
dc.subjectAutistic Disorder
dc.subjectDEAD-box RNA Helicases
dc.titleSocial and emotional characteristics of girls and young women with DDX3X-associated intellectual disability: a descriptive and comparative study.
dc.typeArticle
dcterms.dateAccepted2022-03-09
prism.publicationNameJ Autism Dev Disord
pubs.funder-project-idNewlife – The Charity for Disabled Children (Newlife – The Charity for Disabled Children)
pubs.funder-project-idBaily Thomas Charitable Fund (Baily Thomas Charitable Fund)
pubs.funder-project-idMedical Research Council (G101400)
pubs.funder-project-idNewlife - The Charity for Disabled Children (Newlife - The Charity for Disabled Children)
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1007/s10803-022-05527-w

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