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Comparative genomic mapping reveals mechanisms of chromosome diversification in Rhipidomys species (Rodentia, Thomasomyini) and syntenic relationship between species of Sigmodontinae.

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cam.issuedOnline2021-10-11
dc.contributor.authorPaixão, Vergiana Dos Santos
dc.contributor.authorSuárez, Pablo
dc.contributor.authorOliveira da Silva, Willam
dc.contributor.authorGeise, Lena
dc.contributor.authorFerguson-Smith, Malcolm Andrew
dc.contributor.authorO'Brien, Patricia Caroline Mary
dc.contributor.authorMendes-Oliveira, Ana Cristina
dc.contributor.authorRossi, Rogério Vieira
dc.contributor.authorPieczarka, Julio Cesar
dc.contributor.authorNagamachi, Cleusa Yoshiko
dc.contributor.orcidOliveira da Silva, Willam [0000-0003-3125-1075]
dc.contributor.orcidNagamachi, Cleusa Yoshiko [0000-0003-1516-2734]
dc.date.accessioned2021-11-18T10:35:30Z
dc.date.available2021-11-18T10:35:30Z
dc.date.issued2021
dc.date.updated2021-11-18T10:33:58Z
dc.description.abstractRhipidomys (Sigmodontinae, Thomasomyini) has 25 recognized species, with a wide distribution ranging from eastern Panama to northern Argentina. Cytogenetic data has been described for 13 species with 12 of them having 2n = 44 with a high level of autosomal fundamental number (FN) variation, ranging from 46 to 80, assigned to pericentric inversions. The species are grouped in groups with low FN (46-52) and high FN (72-80). In this work the karyotypes of Rhipidomys emiliae (2n = 44, FN = 50) and Rhipidomys mastacalis (2n = 44, FN = 74), were studied by classical cytogenetics and by fluorescence in situ hybridization using telomeric and whole chromosome probes (chromosome painting) of Hylaeamys megacephalus (HME). Chromosome painting revealed homology between 36 segments of REM and 37 of RMA. We tested the hypothesis that pericentric inversions are the predominant chromosomal rearrangements responsible for karyotypic divergence between these species, as proposed in literature. Our results show that the genomic diversification between the karyotypes of the two species resulted from translocations, centromeric repositioning and pericentric inversions. The chromosomal evolution in Rhipidomys was associated with karyotypical orthoselection. The HME probes revealed that seven syntenic probably ancestral blocks for Sigmodontinae are present in Rhipidomys. An additional syntenic block described here is suggested as part of the subfamily ancestral karyotype. We also define five synapomorphies that can be used as chromosomal signatures for Rhipidomys.
dc.identifier.doi10.17863/CAM.78174
dc.identifier.eissn1932-6203
dc.identifier.issn1932-6203
dc.identifier.otherPMC8504764
dc.identifier.other34634084
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/330731
dc.languageeng
dc.language.isoeng
dc.publisherPublic Library of Science (PLoS)
dc.publisher.urlhttp://dx.doi.org/10.1371/journal.pone.0258474
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 1932-6203
dc.sourcenlmid: 101285081
dc.subjectAnimals
dc.subjectIn Situ Hybridization, Fluorescence
dc.subjectRodentia
dc.subjectSigmodontinae
dc.titleComparative genomic mapping reveals mechanisms of chromosome diversification in Rhipidomys species (Rodentia, Thomasomyini) and syntenic relationship between species of Sigmodontinae.
dc.typeArticle
dcterms.dateAccepted2021-09-28
prism.issueIdentifier10
prism.publicationNamePLoS One
prism.volume16
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1371/journal.pone.0258474

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