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Early levels of GFAP and NF-L in predicting the outcome of mild TBI

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cam.issuedOnline2019-01-08
dc.contributor.authorhossain, Iftakher
dc.contributor.authorMohammadian, Mehrbod
dc.contributor.authorTakala, Riikka
dc.contributor.authorTenovuo, Olli
dc.contributor.authorLagerstedt, Linnéa
dc.contributor.authorAla-Seppälä, Henna
dc.contributor.authorFrantzén, Janek
dc.contributor.authorvan Gils, Mark
dc.contributor.authorHutchinson, Peter
dc.contributor.authorKatila, Ari
dc.contributor.authorMaanpää, Henna-Riikka
dc.contributor.authorMenon, David
dc.contributor.authorNewcombe, virginia
dc.contributor.authorTallus, Jussi
dc.contributor.authorHrusovsky, Kevin
dc.contributor.authorWilson, David
dc.contributor.authorBlennow, Kaj
dc.contributor.authorSanchez, Jean-Charles
dc.contributor.authorZetterberg, Henrik
dc.contributor.authorPosti, Jussi
dc.contributor.orcidHutchinson, Peter [0000-0002-2796-1835]
dc.contributor.orcidMenon, David [0000-0002-3228-9692]
dc.contributor.orcidNewcombe, Virginia [0000-0001-6044-9035]
dc.date.accessioned2019-01-16T00:31:34Z
dc.date.available2019-01-16T00:31:34Z
dc.date.issued2019
dc.description.abstractThe purpose of this study was to correlate the early levels of glial fibrillary acidic protein (GFAP) and neurofilament light protein (NF-L) with outcome in patients with mild traumatic brain injury (mTBI). 107 patients with mTBI [Glasgow Coma Scale (GCS) ≥13] having the blood samples for GFAP and NF-L available within 24 hrs from arrival were included. Patients with mTBI were divided into computed tomography (CT)-positive and CT-negative groups. Glasgow Outcome Scale extended (GOSE) was used to assess the outcome. Outcomes were defined as complete (GOSE 8) vs. incomplete (GOSE <8), and favorable (GOSE 5-8) vs. unfavorable (GOSE 1-4). GFAP and NF-L concentrations in blood were measured using ultrasensitive single molecule array technology. Patients with incomplete recovery had significantly higher levels of NF-L compared to those with complete recovery (p=0.005). The levels of GFAP and NF-L were significantly higher in patients with unfavorable outcome than in patients with favorable outcome (p=0.002 for GFAP and p <0.001 for NF-L). For predicting favorable outcome, the area under the ROC curve for GFAP and NF-L was 0.755 and 0.826, respectively. In a multivariate logistic regression model, the level of NF-L was still a significant predictor for complete recovery (OR=1.008, 95%CI, 1.000-1.016). Moreover, the level of NF-L was a significant predictor for complete recovery in CT-positive patients (OR=1.009, 95%CI, 1.001-1.016). The early levels of GFAP and NF-L are significantly correlated with the outcome in patients with mTBI. The level of NF-L within 24 hrs from arrival has a significant predictive value in mTBI also in a multivariate model.
dc.description.sponsorshipThis work was partially funded by the European Commission under the 7th Framework Programme (FP7-270259-TBIcare), Integra EANS Research Grant (IH), University of Turku Graduate School funding (MM), Government’s Special Financial Transfer tied to academic research in Health Sciences (JPP, RSKT), and personal grants from Emil Aaltonen Foundation sr and Finnish Brain Foundation sr (JPP)
dc.identifier.doi10.17863/CAM.35372
dc.identifier.eissn1557-9042
dc.identifier.issn0897-7151
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/288053
dc.language.isoeng
dc.publisherMary Ann Liebert
dc.subjectGFAP
dc.subjectNF-L
dc.subjectoutcome
dc.subjecttraumatic brain injury
dc.titleEarly levels of GFAP and NF-L in predicting the outcome of mild TBI
dc.typeArticle
dcterms.dateAccepted2018-10-18
prism.publicationNameJournal of Neurotrauma
pubs.funder-project-idAcademy of Medical Sciences (unknown)
pubs.funder-project-idEuropean Commission (270259)
rioxxterms.licenseref.startdate2018-10-18
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionAM
rioxxterms.versionofrecord10.1089/neu.2018.5952

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