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The alpha-ketoacid dehydrogenase complexes of Drosophila melanogaster.

Published version
Peer-reviewed

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Type

Article

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Abstract

The conserved family of alpha-ketoacid dehydrogenase complexes (AKDHCs) catalyze essential reactions in central metabolism and their dysregulation is implicated in several human diseases. Drosophila melanogaster provides an excellent model system to study the genetics and functions of these complexes. However, a systematic account of Drosophila AKDHCs and their composition has been lacking. Here, I identify and classify the genes encoding all Drosophila AKDHC subunits, update their functional annotations and integrate this work into the FlyBase database.

Description

Keywords

3101 Biochemistry and Cell Biology, 3105 Genetics, 31 Biological Sciences, Genetics, 1 Underpinning research, 1.1 Normal biological development and functioning, Generic health relevance

Journal Title

microPublication Biology

Conference Name

Journal ISSN

2578-9430
2578-9430

Volume Title

Publisher

Caltech Library
Sponsorship
National Institutes of Health (NIH) (via Indiana University) (RF2122-21-305)