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The alpha-ketoacid dehydrogenase complexes of Drosophila melanogaster.

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Peer-reviewed

Repository URI

https://www.repository.cam.ac.uk/handle/1810/367830

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Primary Published version (415.75 KB)

Type

Article

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Authors

Marygold, Steven  ORCID logo  https://orcid.org/0000-0003-2759-266X

Abstract

The conserved family of alpha-ketoacid dehydrogenase complexes (AKDHCs) catalyze essential reactions in central metabolism and their dysregulation is implicated in several human diseases. Drosophila melanogaster provides an excellent model system to study the genetics and functions of these complexes. However, a systematic account of Drosophila AKDHCs and their composition has been lacking. Here, I identify and classify the genes encoding all Drosophila AKDHC subunits, update their functional annotations and integrate this work into the FlyBase database.

Description

Keywords

3101 Biochemistry and Cell Biology, 3105 Genetics, 31 Biological Sciences, Genetics, Generic health relevance

Journal Title

microPublication Biology

Conference Name

Journal ISSN

2578-9430
2578-9430

Volume Title

Publisher

Caltech Library

Publisher DOI

https://doi.org/10.17912/micropub.biology.001209

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Attribution 4.0 International
Except where otherwised noted, this item's license is described as Attribution 4.0 International
Sponsorship
National Institutes of Health (NIH) (via Indiana University) (RF2122-21-305)

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University of Cambridge Research Outputs (Articles and Conferences)