Flow synthesis of cyclobutanones $\textit{via}$ [2 + 2] cycloaddition of keteneiminium salts and ethylene gas
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Peer-reviewed
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Change log
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Abstract
A flow chemistry process for the synthesis of 2-substituted cyclobutanones, $\textit{via}$ [2+2] cycloaddition of keteneiminium salts and ethylene gas, is reported. Our approach uses rapid and mild reaction conditions to access a diverse array of products with good to excellent yield, alongside a good level of functional group compatibility.
Description
Journal Title
Reaction Chemistry & Engineering
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Journal ISSN
2058-9883
2058-9883
2058-9883
Volume Title
2
Publisher
Royal Society of Chemistry
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Except where otherwised noted, this item's license is described as Attribution 4.0 International
Sponsorship
Engineering and Physical Sciences Research Council (EP/K009494/1)
Engineering and Physical Sciences Research Council (EP/M004120/1)
Engineering and Physical Sciences Research Council (EP/K039520/1)
Engineering and Physical Sciences Research Council (EP/M004120/1)
Engineering and Physical Sciences Research Council (EP/K039520/1)
The authors would like to thank Syngenta Crop Protection (CB) and the EPSRC (SVL, grants EP/K009494/1, EP/M004120/1 and EP/K039520/1) for financial support.