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Flow synthesis of cyclobutanones $\textit{via}$ [2 + 2] cycloaddition of keteneiminium salts and ethylene gas

Published version
Peer-reviewed

Repository URI

https://www.repository.cam.ac.uk/handle/1810/262969

Repository DOI

https://doi.org/10.17863/CAM.8270

Files

Published version (1.47 MB)
 Accepted version (3.9 MB)

Type

Article

Change log

Authors

Battilocchio, Claudio  ORCID logo  https://orcid.org/0000-0002-4601-8527
Iannucci, G 
Wang, S 
Godineau, E 
Krieger, A 
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Abstract

A flow chemistry process for the synthesis of 2-substituted cyclobutanones, via [2+2] cycloaddition of keteneiminium salts and ethylene gas, is reported. Our approach uses rapid and mild reaction conditions to access a diverse array of products with good to excellent yield, alongside a good level of functional group compatibility.

Description

Keywords

3402 Inorganic Chemistry, 3405 Organic Chemistry, 34 Chemical Sciences

Journal Title

Reaction Chemistry & Engineering

Conference Name

Journal ISSN

2058-9883
2058-9883

Volume Title

2

Publisher

Royal Society of Chemistry

Publisher DOI

https://doi.org/10.1039/C7RE00020K

Rights

Attribution 4.0 International Repository logo
Sponsorship
Engineering and Physical Sciences Research Council (EP/K009494/1)
Engineering and Physical Sciences Research Council (EP/M004120/1)
Engineering and Physical Sciences Research Council (EP/K039520/1)
The authors would like to thank Syngenta Crop Protection (CB) and the EPSRC (SVL, grants EP/K009494/1, EP/M004120/1 and EP/K039520/1) for financial support.
Relationships
Is supplemented by:
https://doi.org/10.17863/CAM.7110

Collections

Scholarly Works - Chemistry
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