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Research data supporting "Glutamatergic and Serotonergic Modulation of Rat Medial and Lateral Orbitofrontal Cortex in Visual Serial Reversal Learning"

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Hervig, Mona El-Sayed 
Piilgaard, Louise 
Bozic, Tadej 
Robbins, Trevor W 


Much evidence suggests that cognitive flexibility, which can be operationalized in reversal learning tasks, is mediated by cortico-striatal circuitries, with the orbitofrontal cortex (OFC) playing a prominent role. We investigated the effects on reversal learning of pharmacological overactivation of the lateral and medial orbitofrontal cortex (lOFC, mOFC) using a glutamate transporter 1 (GLT-1) inhibitor, dihydrokainate (DHK), which increases extracellular glutamate by blocking its reuptake. We also tested the impact of antagonism of the serotonin 2A receptor (5-HT2AR), which modulates glutamate action, in the mOFC and lOFC on the same task.

Each .csv file corresponds to one experiment: reversal learning data from mOFC & lOFC, with rats receiving either the glutamate transporter 1 (GLT-1) inhibitor, dihydrokainate (DHK) or the antagonist of the serotonin 2A receptor (M-100,907).


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glutamate, orbitofrontal cortex, prefrontal cortex, reversal learning, serotonin


Wellcome Trust (104631/Z/14/Z)
This work was supported by a Wellcome Trust Senior Investigator Grant to TWR (104631/Z/14/Z) and a Lundbeck Foundation Research Fellowship to MEH (R182-2014–2810 and R210-2015–2982).