Histidine metabolism boosts cancer therapy.

Accepted version
Repository URI
https://www.repository.cam.ac.uk/handle/1810/284486
Repository DOI
https://doi.org/10.17863/CAM.31862
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Accepted version (15.98 KB)
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Article
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Abstract

Clinical use of the anticancer drug methotrexate can be limited by its high toxicity. It emerges that a diet rich in the amino acid histidine increases the effectiveness of methotrexate treatment and lowers toxicity in mice.

Description
Keywords
Cancer, Medical research, Metabolism, Histidine, Humans, Methotrexate, Mutation, Neoplasms, Research
Journal Title
Nature
Conference Name
Journal ISSN
0028-0836
1476-4687
Volume Title
559
Publisher
Springer Science and Business Media LLC
Publisher DOI
https://doi.org/10.1038/d41586-018-05573-4
Rights
http://www.rioxx.net/licenses/all-rights-reserved
Sponsorship
MRC (unknown)
Medical Research Council (MC_UU_12022/6)
Collections
Cambridge University Research Outputs