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Research data supporting "Brain connectivity during propofol sedation"

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Chennu, Srivas 
O’ Connor, Stuart 
Adapa, Ram 
Menon, David K. 
Bekinschtein, Tristan A. 


This is the final version of the article. It was first available from PLOS via

The data are electroencephalograms of electrical brain activity recorded in 20 healthy participants who were given the sedative propofol. For each participant, there are 4 datasets each with approximately 7 minutes of 91-channel EEG at rest, recorded at baseline, during mild sedation, moderate sedation, and finally at recovery. The EEG data have been filtered between 0.5-45Hz, segmented into 10-second epochs, cleaned and preprocessed to remove artefact, and referenced to the average of all channels. The datasets are in EEGLAB format.

For each dataset, there is an entry in the MATLAB table stored in the file datainfo.mat included. This entry specifies, in order:

  1. the name of the dataset

  1. the level of sedation at which the dataset was acquired (1 = baseline, 2 = mild sedation, 3 = moderate sedation, 4 = recovery)

  1. the concentration of propofol measured in blood plasma at that level (in microgram/litre)

  1. the average reaction times measured in a speeded two-choice response task administered at that level (in milliseconds)

  1. the number of correct responses in that task (out of a max of 40)


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Consciousness, Electroencephalography, Sedation, Propofol, Brain Connectivity


University of Cambridge
This work was supported by grants from the James S. McDonnell Foundation, the Wellcome Trust [WT093811MA to TAB], and the British Oxygen Professorship from the Royal College of Anaesthetists [to DKM]. The research was also supported by the NIHR Brain Injury Healthcare Technology Co-operative based at Cambridge University Hospitals NHS Foundation Trust and University of Cambridge. The views expressed are those of the authors and not necessarily those of the UK National Health Service, the NIHR or the UK Department of Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.