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Oxidative trifluoromethylation of unactivated olefins: an efficient and practical synthesis of α-trifluoromethyl-substituted ketones.

Accepted version
Peer-reviewed

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Type

Article

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Authors

Deb, Arghya 
Modak, Atanu 
Patra, Tuhin 
Maity, Soham 

Abstract

An economical approach to α-CF3-substituted ketones, which are important intermediates in synthetic and medicinal chemistry, employs olefins and the readily available Langlois reagent (CF3SO 2Na). The reaction is operationally simple, proceeds at room temperature, and exhibits an excellent tolerance toward a wide variety of functional groups. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Description

Keywords

Langlois reagent, ketones, olefins, synthetic methods, trifluoromethylation, Alkenes, Fluorine, Ketones, Methylation, Oxidation-Reduction, Temperature

Journal Title

Angew Chem Int Ed Engl

Conference Name

Journal ISSN

1433-7851
1521-3773

Volume Title

52

Publisher

Wiley