Avoiding monetary loss: A human habenula functional MRI ultra-high field study.


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Authors
Weidacker, Kathrin 
Kim, Seung-Goo 
Nord, Camilla L 
Rua, Catarina 
Rodgers, Christopher T 
Abstract

A number of convergent human neuroimaging and animal studies suggest that habenula neurons fire in anticipation of non-rewarding outcomes, and suppress their firing in anticipation of rewarding outcomes. This normative function of the habenula appears disrupted in depression, and may be critical to the anti-depressant effects of ketamine. However, studying habenula functionality in humans using standard 3 T MRI is inherently limited by its small size. We employed ultra-high field (7 T) fMRI to investigate habenular activity in eighteen healthy volunteers during a Monetary Incentive Delay Task, focussing on loss avoidance, monetary loss and neutral events. We assessed neural activation in the field of view (FOV) in addition to ROI-based habenula-specific activity and generalized task-dependent functional connectivity. Whole FOV results indicated substantial neural differences between monetary loss and neutral outcomes, as well as between loss avoidance and neutral outcomes. Habenula-specific analyses showed bilateral deactivation during loss avoidance, compared to other outcomes. This first investigation into the habenula's role during loss avoidance revealed that the left habenula further differentiated between loss avoidance and monetary loss. Functional connectivity between the right habenula and the ipsilateral hippocampus and subcallosal cingulate (regions implicated in memory and depression pathophysiology) was enhanced when anticipating potential losses compared to anticipating neutral outcomes. Our findings suggest that the human habenula responds most strongly to outcomes of loss avoidance when compared to neutral and monetary losses, suggesting a role for the habenula in both reward and aversive processing. This has critical relevance to understanding the pathophysiology of habenula function in mood and other neuropsychiatric disorders, as well as the mechanism of action of habenula-targeting antidepressants such as ketamine.

Description
Keywords
Functional connectivity, Habenula, Loss avoidance, Monetary incentive delay task, Reward processing, Animals, Anticipation, Psychological, Habenula, Humans, Magnetic Resonance Imaging, Motivation, Neuroimaging, Reward
Journal Title
Cortex
Conference Name
Journal ISSN
0010-9452
1973-8102
Volume Title
142
Publisher
Elsevier BV
Rights
All rights reserved
Sponsorship
Wellcome Trust (Unknown)
Wellcome Trust (098436/Z/12/B)
Medical Research Council (MR/P008747/1)
MRC (Unknown)
Medical Research Council (MR/M008983/1)
MRC (MR/M008983/1)
Medical Research Council (MC_UU_00005/4)
National Institute for Health and Care Research (IS-BRC-1215-20014)
MRC (MC_UU_00030/12)
This research was supported by the NIHR Cambridge Biomedical Research Centre (BRC-1215-20014). VV is funded by a Medical Research Council Senior Fellowship (MR/P008747/1). CLN is funded by the Medical Research Council (Grant Reference: SUAG/043 G101400). CTR is funded by a Sir Henry Dale Fellowship from the Wellcome Trust and the Royal Society [098436/Z/12/B]. The 7T MRI scanner was funded by the University of Cambridge, the Medical Research Council (MR/M008983/1), and the NIHR Cambridge Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care.
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