Repository logo
 

Prodrugs of Pyrophosphates and Bisphosphonates: Disguising Phosphorus Oxyanions

Published version
Peer-reviewed

Type

Article

Change log

Authors

Rudge, Emma S 
Chan, Alex HY 

Abstract

Pyrophosphates have important functions in living systems and thus pyrophosphate-containing molecules and their more stable bisphosphonate analogues have the potential to be used as drugs for treating many diseases including cancer and viral infections. Both pyrophosphates and bisphosphonates are polyanionic at physiological pH and, whilst this is essential for their biological activity, it also limits their use as therapeutic agents. In particular, the high negative charge density of these compounds prohibits cell entry other than by endocytosis, prevents transcellular oral absorption and causes sequestration to bone. Therefore, prodrug strategies have been developed to temporarily disguise the charges of these compounds. This review examines the various systems that have been used to mask the phosphorus-containing moieties of pyrophosphates and bisphosphonates and also illustrates the utility of such prodrugs.

Description

Keywords

3404 Medicinal and Biomolecular Chemistry, 3405 Organic Chemistry, 34 Chemical Sciences, Infectious Diseases, Orphan Drug, Emerging Infectious Diseases, Rare Diseases, Cancer, 15 Life on Land

Journal Title

RSC Medicinal Chemistry

Conference Name

Journal ISSN

2632-8682
2632-8682

Volume Title

13

Publisher

Royal Society of Chemistry
Sponsorship
Kwong Mei Medhealth