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Understanding Alzheimer's disease as a disorder of consciousness.

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cam.issuedOnline2021-11-29
dc.contributor.authorHuntley, Jonathan D
dc.contributor.authorFleming, Stephen M
dc.contributor.authorMograbi, Daniel C
dc.contributor.authorBor, Daniel
dc.contributor.authorNaci, Lorina
dc.contributor.authorOwen, Adrian M
dc.contributor.authorHoward, Robert
dc.date.accessioned2021-12-15T11:11:11Z
dc.date.available2021-12-15T11:11:11Z
dc.date.issued2021
dc.date.submitted2021-01-12
dc.date.updated2021-12-15T11:11:10Z
dc.description.abstractPeople with Alzheimer's disease (AD) demonstrate a range of alterations in consciousness. Changes in awareness of cognitive deficit, self-awareness, and introspection are seen early in AD, and dysfunction of awareness and arousal progresses with increasing disease severity. However, heterogeneity of deficits between individuals and a lack of empirical studies in people with severe dementia highlight the importance of identifying and applying biomarkers of awareness in AD. Impairments of awareness in AD are associated with neuropathology in regions that overlap with proposed neural correlates of consciousness. Recent developments in consciousness science provide theoretical frameworks and experimental approaches to help further understand the conscious experience of people with AD. Recognition of AD as a disorder of consciousness is overdue, and important to both understand the lived experience of people with AD and to improve care.
dc.identifier.doi10.17863/CAM.78925
dc.identifier.eissn2352-8737
dc.identifier.issn2352-8737
dc.identifier.othertrc212203
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331471
dc.languageen
dc.language.isoeng
dc.publisherWiley
dc.publisher.urlhttp://dx.doi.org/10.1002/trc2.12203
dc.subjectAlzheimer's disease
dc.subjectawareness
dc.subjectconsciousness
dc.titleUnderstanding Alzheimer's disease as a disorder of consciousness.
dc.typeArticle
dcterms.dateAccepted2021-07-28
prism.issueIdentifier1
prism.publicationNameAlzheimers Dement (N Y)
prism.volume7
pubs.funder-project-idWellcome Clinical Research Career Development Fellowship (214547/Z/18/Z)
pubs.funder-project-idWellcome/Royal Society Sir Henry Dale Fellowship (206648/Z/17/Z)
pubs.funder-project-idWellcome Trust (206648/Z/17/Z, 210920/Z/18/Z)
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1002/trc2.12203

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