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Mesenchymal Stem Cell-Derived Extracellular Vesicles in Tendon and Ligament Repair-A Systematic Review of In Vivo Studies.

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cam.issuedOnline2021-09-27
dc.contributor.authorLu, Victor
dc.contributor.authorTennyson, Maria
dc.contributor.authorZhang, James
dc.contributor.authorKhan, Wasim
dc.contributor.orcidLu, Victor [0000-0002-6818-1683]
dc.contributor.orcidKhan, Wasim [0000-0003-3106-5424]
dc.date.accessioned2022-01-06T11:51:06Z
dc.date.available2022-01-06T11:51:06Z
dc.date.issued2021-09-27
dc.date.updated2022-01-06T11:51:06Z
dc.description.abstractTendon and ligament injury poses an increasingly large burden to society. This systematic review explores whether mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) can facilitate tendon/ligament repair in vivo. On 26 May 2021, a systematic search was performed on PubMed, Web of Science, Cochrane Library, Embase, to identify all studies that utilised MSC-EVs for tendon/ligament healing. Studies administering EVs isolated from human or animal-derived MSCs into in vivo models of tendon/ligament injury were included. In vitro, ex vivo, and in silico studies were excluded, and studies without a control group were excluded. Out of 383 studies identified, 11 met the inclusion criteria. Data on isolation, the characterisation of MSCs and EVs, and the in vivo findings in in vivo models were extracted. All included studies reported better tendon/ligament repair following MSC-EV treatment, but not all found improvements in every parameter measured. Biomechanics, an important index for tendon/ligament repair, was reported by only eight studies, from which evidence linking biomechanical alterations to functional improvement was weak. Nevertheless, the studies in this review showcased the safety and efficacy of MSC-EV therapy for tendon/ligament healing, by attenuating the initial inflammatory response and accelerating tendon matrix regeneration, providing a basis for potential clinical use in tendon/ligament repair.
dc.identifier.doi10.17863/CAM.79609
dc.identifier.eissn2073-4409
dc.identifier.issn2073-4409
dc.identifier.otherPMC8533909
dc.identifier.other34685532
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332163
dc.languageeng
dc.language.isoeng
dc.publisherMDPI AG
dc.publisher.urlhttp://dx.doi.org/10.3390/cells10102553
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2073-4409
dc.sourcenlmid: 101600052
dc.subjectbiomechanics
dc.subjectcollagen
dc.subjectextracellular vesicles
dc.subjectligament
dc.subjectmacrophage
dc.subjectmesenchymal stem cells
dc.subjecttendon
dc.subjectAnimals
dc.subjectExtracellular Vesicles
dc.subjectHumans
dc.subjectLigaments
dc.subjectMesenchymal Stem Cells
dc.subjectMice
dc.subjectRats
dc.subjectTendon Injuries
dc.subjectTendons
dc.titleMesenchymal Stem Cell-Derived Extracellular Vesicles in Tendon and Ligament Repair-A Systematic Review of In Vivo Studies.
dc.typeArticle
dcterms.dateAccepted2021-09-22
prism.issueIdentifier10
prism.publicationNameCells
prism.volume10
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.3390/cells10102553

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